Blood Substitutes and Oxygen Therapeutics: A Review

Publication Date

2021

Journal Title

Anesth Analg

Abstract

Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood transfusion is not an option, due to patient's religious beliefs, inability to find adequately cross-matched erythrocytes, or in remote locations. In these situations, artificial oxygen carriers may provide a mortality benefit for patients with severe, life-threatening anemia. This article provides an up-to-date review of the history and development, clinical trials, new technology, and current standing of artificial oxygen carriers as an alternative to transfusion when blood is not an option.

Volume Number

132

Issue Number

1

Pages

119 - 129

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Anesthesiology

PMID

30925560

DOI

10.1213/ANE.0000000000003957

For the public and Northwell Health campuses

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