Single versus multiple session stereotactic body radiotherapy for spinal metastasis: the risk-benefit ratio

Publication Date

2015

Journal Title

Future Oncol

Abstract

Spine stereotactic body radiation therapy represents an important advancement in the management of spinal metastases that allows precise delivery of ablative doses of radiation therapy with excellent local control. Although the technique is being increasingly used in clinical practice, the optimal fractionation schedule remains uncertain. In this perspective paper, we review radiobiologic principles that support the use of multiple- versus single-fraction spine stereotactic body radiation therapy schedules and clinical data supporting the multiple-fraction approach. Specifically, we suggest that there may be a local control benefit of fractionation, while helping to limit the risk of toxicities such as vertebral body fracture, pain flare and radiation myelopathy. We conclude with future directions and the need for future study on this important topic.

Volume Number

11

Issue Number

17

Pages

2405-15

Document Type

Article

EPub Date

2015/09/16

Status

Faculty

Facility

School of Medicine

Primary Department

Radiation Medicine

PMID

26369361

DOI

10.2217/fon.15.160

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