QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009
Publication Date
2015
Journal Title
Hum Psychopharmacol
Abstract
ObjectiveLittle is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. MethodData on 3482 hospitalized schizophrenia patients (2004=1826 and 2008/2009=1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. ResultsThe frequency of QTc prolongation (>456ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p=0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values
Volume Number
30
Issue Number
2
Pages
94-99
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Psychiatry
Additional Departments
Molecular Medicine
PMID
DOI
10.1002/hup.2458