Author ORCID Identifier(s)
Date of Award
9-2024
Document Type
Thesis
Degree Name
Doctor of Philosophy (PhD)
First Advisor
Lior Brimberg
Abstract
This project adds to the growing body of literature linking maternal anti-brain antibodies to the presence of ASD in offspring. We have previously detailed the ASD-like phenotype observed in male, but not female following exposure in utero to anti-Caspr2 IgG.79,380 The structural and behavioral phenotype in males exposed in utero to anti-Caspr2 IgG includes thinning of the cortical plate, reduction in parvalbumin interneurons in the hippocampus, reduced dendritic arborization and dendritic spine density of CA1 hippocampal pyramidal neurons, increased repetitive behavior, and reduced social behavior.380 In this work, we discover changes in microglia in male offspring exposed in utero to maternal anti-Caspr2 IgG and propose the BBB-crossing ACE inhibitor captopril as a novel therapeutic to ameliorate the cellular and behavioral phenotype observed in these mice.
Recommended Citation
Spielman, Ben, "The Role of Microglia in a Mouse Model of Maternal Anti-Caspr2 Antibody- Induced Autism Spectrum Disorder (ASD)" (2024). Donald and Barbara Zucker School of Medicine Theses and Dissertations. 56.
https://academicworks.medicine.hofstra.edu/zsom_dissertations/56