Myelodysplastic syndromes spatial clusters in disease etiology and outcome
Publication Date
2015
Journal Title
Leuk Lymphoma
Abstract
The myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic disorders. This study aims to advance the use of spatial modeling in disease etiology and monitoring based on reports on a large population (n = 984) of MDS patients diagnosed in the Eastern United States. The spatial MDS clustering was analyzed using SaTScan, and patient clinical characteristics were analyzed using logistic regression and Cox hazards models adjusting for covariates. One main and five secondary spatial clusters (p-value < 10-17-10-7) were identified. Patients living in high vs. low MDS incidence clusters tended to be older (ORadj = 1.04 [1.004, 1.07]) and smokers (ORadj = 2.9 [1.1, 7.4]). Mortality was associated with hemoglobin (HRadj = 0.7 [0.5, 0.9]), neutrophils (HRadj = 0.7 [0.6, 0.96]), platelets (HRadj = 0.5 [0.4, 0.7]), and blast (HRadj = 1.4 [1.1, 1.8]), but not clusters. The results suggest large geographic variations in MDS incidence rates. The biological aggressiveness of the disease is unlikely to be associated with its spatial distribution.
Pages
1-8
Document Type
Article
EPub Date
2015/07/15
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Occupational Medicine, Epidemiology and Prevention
Additional Departments
Hematology/Medical Oncology
PMID
DOI
10.3109/10428194.2015.1071487