Publication Date

2015

Journal Title

PLoS One

Abstract

BACKGROUND: Recent studies reported seasonal differences in gene expression in white blood cells, adipose tissue, and inflammatory biomarkers of the immune system. There is no data on the seasonal variations of these biomarkers in the US general population of both children and adults. Then aim of this study is to explore the seasonal trends in complete blood count (CBC), and C-reactive protein (CRP) in a large non-institutionalized US population. METHODS: Seven cross-sectional data collected in the National Health and Nutrition Examination Survey (NHANES) during 1999-2012 were aggregated; participants reporting recent use of prescribed steroids, chemotherapy, immunomodulators and antibiotics were excluded. Linear regression models were used to compare levels of CBC and CRP between winter-spring (November-April) and summer-fall (May-October), adjusting for demographics, personal behavioral factors, and chronic disease conditions. RESULTS: A total of 27,478 children and 36,644 adults (>/=18 years) were included in the study. Levels of neutrophils, white blood cell count (WBC), and CRP were higher in winter-spring than summer-fall (p

Volume Number

10

Issue Number

11

Pages

e0142382

Document Type

Article

EPub Date

2015/11/07

Status

Faculty, Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Occupational Medicine, Epidemiology and Prevention

PMID

26544180

DOI

10.1371/journal.pone.0142382


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