Publication Date
2015
Journal Title
PLoS One
Abstract
BACKGROUND: Recent studies reported seasonal differences in gene expression in white blood cells, adipose tissue, and inflammatory biomarkers of the immune system. There is no data on the seasonal variations of these biomarkers in the US general population of both children and adults. Then aim of this study is to explore the seasonal trends in complete blood count (CBC), and C-reactive protein (CRP) in a large non-institutionalized US population. METHODS: Seven cross-sectional data collected in the National Health and Nutrition Examination Survey (NHANES) during 1999-2012 were aggregated; participants reporting recent use of prescribed steroids, chemotherapy, immunomodulators and antibiotics were excluded. Linear regression models were used to compare levels of CBC and CRP between winter-spring (November-April) and summer-fall (May-October), adjusting for demographics, personal behavioral factors, and chronic disease conditions. RESULTS: A total of 27,478 children and 36,644 adults (>/=18 years) were included in the study. Levels of neutrophils, white blood cell count (WBC), and CRP were higher in winter-spring than summer-fall (p
Volume Number
10
Issue Number
11
Pages
e0142382
Document Type
Article
EPub Date
2015/11/07
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Occupational Medicine, Epidemiology and Prevention
PMID
DOI
10.1371/journal.pone.0142382
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