Carfilzomib-related acute kidney injury may be prevented by N-acetyl-L-cysteine

Publication Date

2014

Journal Title

J Oncol Pharm Pract

Abstract

Carfilzomib is a second-generation epoxyketone proteasome inhibitor that is approved for treatment of relapsed and refractory multiple myeloma. Phase 2 trials have reported that 25% of treated patients have renal adverse effects. Pre-renal/vasoconstriction-related insult from this chemotherapy agent has been documented. We describe a case of a 78-year-old man with refractory multiple myeloma with acute kidney injury associated with carfilzomib treatment. We show that use of N-acetyl-l-cysteine in our patient partially mitigated the renal injury upon re-challenge. This case report hypothesizes that acute renal injury from carfilzomib is caused by vasoconstriction of the renal vessels, which may be prevented by N-acetyl-l-cysteine.

Volume Number

21

Issue Number

4

Pages

313-6

Document Type

Article

EPub Date

2014/04/22

Status

Faculty

Facility

School of Medicine

Primary Department

Nephrology

Additional Departments

Hematology/Medical Oncology

PMID

24748581

DOI

10.1177/1078155214531804

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