Publication Date

2014

Journal Title

Expert Opin Ther Targets

Abstract

Introduction: Sepsis refers to the host's deleterious and non-resolving systemic inflammatory response to microbial infections and represents the leading cause of death in the intensive care unit. The pathogenesis of sepsis is complex, but partly mediated by a newly identified alarmin molecule, the high mobility group box 1 (HMGB1). Areas covered: Here we review the evidence that support extracellular HMGB1 as a late mediator of experimental sepsis with a wider therapeutic window and discuss the therapeutic potential of HMGB1-neutralizing antibodies and small molecule inhibitors (herbal components) in experimental sepsis. Expert opinion: It will be important to evaluate the efficacy of HMGB1-targeting strategies for the clinical management of human sepsis in the future.

Volume Number

18

Issue Number

3

Pages

257-268

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Emergency Medicine

PMID

24392842

DOI

10.1517/14728222.2014.863876


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