Publication Date

2015

Journal Title

AIDS Res Hum Retroviruses

Abstract

HIV may induce gastrointestinal (GI) mucosal immune dysregulation similar to inflammation observed in ulcerative colitis (UC). Colorectal biopsies from healthy controls (N=12) and from participants with HIV (N=20) or UC (N=9) were subjected to real time (RT)-PCR for selected cytokines, chemokines, antimicrobial peptides, Toll-like receptors, and inflammatory signaling and epithelial barrier proteins. HIV long terminal repeat relative copy number (RCN) in HIV participant biopsies was quantified by RT-PCR. Mean interleukin (IL)-6 mRNA levels did not differ significantly between HIV and UC participants (p=0.48) but were significantly higher relative to control mRNA levels only for HIV participants (p=0.03). Mean IL-8 and human defensin (HD) 5 mRNA levels were similar between HIV and UC participants (p=1.0 and p=0.35, respectively) and were significantly greater in both groups relative to controls (p

Volume Number

31

Issue Number

6

Pages

615-22

Document Type

Article

EPub Date

2015/03/15

Status

Northwell Researcher

Facility

Northwell Health

Primary Department

General Pediatrics

PMID

25768924

DOI

10.1089/aid.2014.0085


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Pediatrics Commons

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