Publication Date
2015
Journal Title
Lupus Sci Med
Abstract
BACKGROUND: Although an early decrease in proteinuria has been correlated with good long-term renal outcome in lupus nephritis (LN), studies aimed at defining a cut-off proteinuria value are missing, except a recent analysis performed on patients randomised in the Euro-Lupus Nephritis Trial, demonstrating that a target value of 0.8 g/day at month 12 optimised sensitivity and specificity for the prediction of good renal outcome. The objective of the current work is to validate this target in another LN study, namely the MAINTAIN Nephritis Trial (MNT). METHODS: Long-term (at least 7 years) renal function data were available for 90 patients randomised in the MNT. Receiver operating characteristic curves were built to test the performance of proteinuria measured within the 1st year as short-term predictor of long-term renal outcome. We calculated the positive and negative predictive values (PPV, NPV). RESULTS: After 12 months of treatment, achievement of a proteinuria
Volume Number
2
Issue Number
1
Pages
e000123
Document Type
Article
EPub Date
2015/12/03
Status
Faculty
Facility
School of Medicine
Primary Department
Molecular Medicine
Additional Departments
Allergy and Immunology
PMID
DOI
10.1136/lupus-2015-000123